Makoto Hosoyamada Selected Research

Juvenile gout

8/2015	Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat.
12/2011	Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene.
6/2008	Production and characterization of transgenic mice harboring mutant human UMOD gene.
3/2008	Progressive accumulation of intrinsic mouse uromodulin in the kidneys of transgenic mice harboring the mutant human uromodulin gene.

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Makoto Hosoyamada Research Topics

Disease

9	Renal hypouricemia 12/2021 - 01/2004
6	Gout 01/2020 - 08/2005
5	Hyperuricemia 01/2020 - 01/2011
4	Proteinuria 08/2017 - 11/2004
4	Juvenile gout 08/2015 - 03/2008
3	Inborn Genetic Diseases (Disease, Hereditary) 12/2021 - 12/2011
3	Body Weight (Weight, Body) 01/2020 - 10/2006
3	Nephrosis 08/2017 - 02/2005
3	Albuminuria 01/2017 - 02/2005
3	Acute Kidney Injury (Acute Renal Failure) 12/2016 - 12/2011
2	Alzheimer Disease (Alzheimer's Disease) 09/2020 - 03/2010
2	Renal Insufficiency (Renal Failure) 01/2020 - 01/2011
2	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 08/2017 - 02/2009
2	Chronic Renal Insufficiency 12/2016 - 01/2015
2	Urolithiasis 01/2014 - 12/2003
1	Hyperemia 12/2021
1	Reperfusion Injury 01/2021
1	Brain Ischemia (Cerebral Ischemia) 01/2021
1	Hypothyroidism 01/2021
1	Ischemic Stroke 01/2021
1	Stroke (Strokes) 09/2020
1	Atherosclerosis 01/2020
1	Atherosclerotic Plaque (Atheroma) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Hypertension (High Blood Pressure) 01/2017
1	Vascular Remodeling 01/2017
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2015
1	Ischemia 01/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2013
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2011
1	Obesity 12/2011
1	Nephrolithiasis 12/2011
1	Weight Gain 12/2008
1	Anemia 03/2008
1	Nephrotic Syndrome (Syndrome, Nephrotic) 11/2004

Drug/Important Bio-Agent (IBA)

19	Uric Acid (Urate)IBA 12/2021 - 12/2003
8	urate transporterIBA 12/2021 - 01/2004
5	UromodulinIBA 08/2015 - 03/2008
3	Puromycin AminonucleosideIBA 08/2017 - 02/2005
3	Proteins (Proteins, Gene)FDA Link 12/2011 - 02/2005
2	Urate Oxidase (Uricase)IBA 01/2020 - 12/2016
2	Xanthine OxidaseIBA 01/2020 - 08/2015
2	FYX-051IBA 08/2017 - 08/2015
2	LeptinIBA 12/2011 - 10/2006
2	nephrinIBA 02/2009 - 02/2005
2	NPHS2 proteinIBA 02/2005 - 11/2004
1	endothelium-dependent hyperpolarization factor (EDHF)IBA 12/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 09/2020
1	Biomarkers (Surrogate Marker)IBA 09/2020
1	Interleukin-1 (Interleukin 1)IBA 01/2020
1	HypoxanthineIBA 01/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020
1	NAD (NADH)IBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	TOR Serine-Threonine KinasesIBA 01/2020
1	Oxonic AcidIBA 01/2020
1	AMP-Activated Protein KinasesIBA 01/2020
1	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 01/2020
1	AntioxidantsIBA 08/2017
1	tempolIBA 01/2017
1	8-Hydroxy-2'-DeoxyguanosineIBA 01/2017
1	DesminIBA 01/2017
1	Superoxide DismutaseIBA 01/2017
1	Allopurinol (Remid)FDA LinkGeneric 12/2016
1	purineIBA 08/2015
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2014
1	Ether (Diethyl Ether)IBA 01/2014
1	Adenosine Triphosphate (ATP)IBA 01/2014
1	Cholinergic Antagonists (Anticholinergics)IBA 03/2010
1	Nootropic Agents (Nootropics)IBA 03/2010
1	Galectin 1 (LGALS1)IBA 02/2009
1	1-nitrohydroxyphenyl-N-benzoylalanine (GAL 1)IBA 02/2009
1	Fluvoxamine (Luvox)FDA LinkGeneric 12/2008
1	CadmiumIBA 03/2008
1	Glycoproteins (Glycoprotein)IBA 03/2008
1	Testosterone (Sustanon)FDA Link 10/2006
1	AdiponectinIBA 10/2006
1	Organic Anion TransportersIBA 08/2005
1	Membrane Proteins (Integral Membrane Proteins)IBA 02/2005
1	mouse Slc22a12 proteinIBA 02/2004
1	Complementary DNA (cDNA)IBA 02/2004
1	CreatinineIBA 01/2004
1	Probenecid (Benemid)FDA LinkGeneric 01/2004
1	Pyrazinamide FDA LinkGeneric 01/2004
1	BenzbromaroneIBA 01/2004

Therapy/Procedure

2	Therapeutics 01/2020 - 01/2013
1	Intraperitoneal Injections 08/2017
1	Anesthesia 01/2014